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    邓宏章

    • 教授 博士生导师 研究生导师
    • 主要任职:教授/博士生导师
    • 性别:男
    • 学历:博士研究生毕业
    • 学位:工学博士学位
    • 在职信息:在岗
    • 所在单位:生命科学技术学院
    • 入职时间: 2021-01-10
    • 办公地点:实验室G-546西/G-547西
      办公室F-512
    • 联系方式:hzdeng@xidian.edu.cn
    • 电子邮箱:

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      论文成果



      2024年


      31. Caiyan Zhao, Changrong Wang, Wenbo Shan, Zhongliang Wang*, Xiaoyuan Chen*, and Hongzhang Deng*, Nanomedicines for an enhanced immunogenic cell death-based in situ cancer vaccination response.Accounts of Chemical Research2024, Accepted.https://pubs.acs.org/doi/10.1021/acs.accounts.3c00771


      2023年


      30. Changrong Wang#, Caiyan Zhao#, Weipeng Wang#, Xiaoqing Liu,Hongzhang Deng*, Biomimetic noncationic lipid nanoparticles for mRNA delivery.PNAS,2023, 120, e2311276120.

      29. Xiaoqing Liu, Pei Huang, Rusen Yang,Hongzhang Deng*, mRNA cancer vaccines: construction and boosting strategies.ACS Nano2023, 17, 20,19550–19580.

      28. Pei Huang, Changrong Wang,Hongzhang Deng*, Yongfeng Zhou*, Xiaoyuan Chen*, Surface engineering of nanoparticles toward cancer theranostics.Accounts of Chemical Research2023, 56, 1766-1779.

      27. Jun Zhou, Chen Cao, Xinlu Zhang, Xu, Zhang, Jiansen Li,Hongzhang Deng*, Sheng Wang*, Gas-assisted phototherapy for cancer treatment.Journal of Controlled Release2023, 360, 564-577.

      26. Guang Yang, Changrong Wang*, Yaping Wang, Xiaoqing Liu, Ye Zhang, Ming Xu,Hongzhang Deng*, Weiwei Wang*, Noncovalent co-assembly of aminoglycoside antibiotics@tannic acid nanoparticles for off-the-shelf treatment of pulmonary and cutaneous infections.Chemical Engineering Journal2023, 474, 145703.

      25. Pei Huang#,Hongzhang Deng#, Changrong Wang, Yongfeng Zhou, Xiaoyuan Chen*, Cellular Trafficking of Nanotechnology-Mediated mRNA Delivery.Advaned Materials2023, https://doi.org/10.1002/adma.202307822.

      24. Jing Liu, Yaya Cheng, Haoyu Wang, Dingyi Yang, Cunshun Liu, Weixin Dou, Xue Jiang, Hongzhang Deng*, Rusen Yang*, Regulation of TiO2 @PVDF piezoelectric nanofiber membranes on osteogenic differentiation of mesenchymal stem cells.Nano Energy2023, 115, 108742.

      23. Caiyan Zhao, Yaya Cheng, Pei Huang, Changrong Wang, Weipeng Wang, Mengjiao Wang,Hongzhang Deng*, X-ray guided in situ genetic engineering of macrophage for sustained cancer immunotherapy.Advanced Materials2023, 35, 2208059.

      22. Pei Huang, Lingsheng Jiang, Hui Pan, Lingwen Ding, Bo Zhou, Mengyao Zhao, Jianhua Zou, Benhao Li, Meiwei Qi,Hongzhang Deng*, Yongfeng Zhou*, Xiaoyuan Chen*, Integrated polymeric mRNA vaccine without inflammation side‐effects for cellular immunity mediated cancer therapy.Advanced Materials2023, 35, 2207471.


      2022年


      21. Caiyan Zhao,Hongzhang Deng*, Xiaoyuan Chen*, Harnessing immune response using reactive oxygen species-generating/eliminating inorganic biomaterials for disease treatment.Advanced Drug Delivery Reviews2022,188,114456.

      20. Pei Huang,Hongzhang Deng*, Yongfeng Zhou*, Xiaoyuan Chen*, The roles of polymers in mRNA delivery.Matter2022,5, 1670-1699.

      19.Hongzhang Deng, Zuo Yang, Xiaoyu Pang, Caiyan Zhao*, Jie Tian*, Zhongliang Wang*, Xiaoyuan Chen*, Self-sufficient copper peroxide loaded pKa-tunable nanoparticles for lysosome-mediated chemodynamic therapy,Nano Today2022, 2, 101337.

      18. Caiyan Zhao#, Xiaoyu Pang#, Zuo Yang, Sheng Wang,Hongzhang Deng*, Xiaoyuan Chen*, Nanomaterials targeting tumor associated macrophages for cancer immunotherapy.Journal of Controlled Release2022, 34, 272-284.


      2021年之前


      17.Kuikun Yang, Guocan Yu, Rui Tian, Zijian Zhou, Bo Li,Hongzhang Deng*, Ling Li, Zhen Yang, Guofeng Zhang, Dahai Liu, Jianwen Wei, Ludan Yue, Ruibing Wang* and Xiaoyuan Chen*, Oxygen-evolving manganese ferrite nanovesicles for hypoxia-responsive drug delivery and enhanced cancer chemoimmunotherapy.Advanced Functional Materials2021,31, 2008078.

      16.Hongzhang Deng,Weijing Yang, Zijian Zhou, Rui Tian, Lisen Lin, Ying Ma, Jibin Song*, and Xiaoyuan Chen*, Targeted scavenging of extracellular ROS relieves suppressive immunogenic cell death.Nature Communications2020, 11, 4951.

      15.Hongzhang Deng,Zijian Zhou, Weijing Yang, Lisen Lin, Sheng Wang, Gang Niu, Jibin Song*, and Xiaoyuan Chen*, Endoplasmic reticulum targeting to amplify immunogenic cell death for cancer immunotherapy.Nano Letters2020,20, 1929-1933.

      14.Hongzhang Deng, Lisen Lin, Sheng Wang, Guocan Yu, Zijian Zhou, Yijing Liu, Gang Liu, Jibin Song*, Xiaoyuan Chen*,X-ray-controlled bilayer permeability of bionic nanocapsules stabilized by nucleobase pairing interactions for pulsatile drug delivery.Advanced Materials2019,31, 1903443.

      13.Hongzhang Deng, Anjie Dong, Jibin Song*, Xiaoyuan Chen*, Injectable Thermosensitive hydrogel systems based on functional PEG/PCL block polymer for local drug delivery.Journal of Controlled Release2019, 297, 60-70.

      12.Liandong Deng, Zujian Feng,Hongzhang Deng*, Yujia Jiang, Kun Song, Yongli Shi, Shuangqing Liu, Jianhua Zhang, Suping Bai, Zhihai Qin*, Anjie Dong*, Rational design of nnanoparticles to overcome poor tumor penetration and hypoxia-iinduced chemotherapy resistance: combination of optimizing size and self-inducing high level of reactive oxygen species.ACS Applied Materials & Interfaces2019,11, 31743-31754.

      11.Hongzhang Deng, Kun Song, Jianhua Zhang, Liandong Deng, Anjie Dong*, Zhihai Qin*, Modulating the rigidity of nanoparticles for tumor penetration.Chemical Communications2018,54, 3014-3017.

      10.Gan Chen#,Hongzhang Deng#,(Co-First Author)Xiang Song, Mingzi Lu, Lian Zhao, Sha Xia, Guoxing You, Jingxiang Zhao, Yulong Zhang, Anjie Dong*, Hong Zhou*, Reactive oxygen species-responsive polymeric nanoparticles for alleviating sepsis-induced acute liver injury in mice.Biomaterials2017,144, 30-41.

      9.Hongzhang Deng, Kun Song, Xuefei Zhao, Yanan Li, Fei Wang, Jianhua Zhang, Anjie Dong*, and Zhihai Qin*, Tumor mmicroenvironment activated membrane fusogenic liposome with speedy antibody and doxorubicin delivery for synergistic treatment of metastatic tumors.ACS Applied Materials & Interfaces2017,9, 9315-9326.

      8.Hongzhang Deng, Xuefei Zhao, Liandong Deng, Jianfeng Liu, Anjie Dong*, Reactive oxygen species activated nanoparticles with tumor acidity internalization for precise anticancer therapy.Journal of Controlled Release2017,255, 142-153.

      7.Caiyan Zhao#,Hongzhang Deng#,(Co-First Author)Shuyi Li, Lin Zhong, Leihou Shao, Yan Wu*, Xingjie Liang, "Sheddable" PEG-lipid to balance the contradiction of PEGylation between long circulation and poor uptake.Nanoscale2016,8, 10832-10842.

      6.Hongzhang Deng, Xuefei Zhao, Dongxuan He, Weisheng Guo, Keni Yang, Anjie Dong*, Xingjie Liang*, One-step gene delivery into cytoplasm in a fusion-dependent manner based on a new membrane fusogenic lipid.Chemical Communications2016,52, 7406-7408.

      5.Hongzhang Deng, Jinjian Liu, Xuefei Zhao, Dongxuan He, Zujian Feng, Jianhua Zhang, Jianfeng Liu, Anjie Dong*, Synergistic dual-pH responsive copolymer micelles for pH-dependent drug release.Nanoscale2016,8, 1437-1450.

      4.Hongzhang Deng#, Yuming Zhang#, Xue Wang, Yan Cao, Jinjian Liu, Jianfeng Liu Liandong Deng* Anjie Dong, Balancing the stability and drug release of polymer micelles by the coordination of dual-sensitive cleavable bonds in cross-linked core.Acta Biomaterialia2015,11, 126-136.

      3.Jinjian Liu#,Hongzhang Deng#,(Co-First Author)Qiang Liu, Liping Chu, Yuming Zhang, Cuihong Yang, Xuefei Zhao, Pingsheng Huang, LiandongDeng, Anjie Dong*, Integrin-targeted pH-responsive micelles for enhanced efficiency of anticancer treatment in vitro and in vivo.Nanoscale2015,7, 4451-4460.

      2.Hongzhang Deng, Xuefei Zhao, Jinjian Liu, Liandong Deng, Jianhua Zhang, Jianfeng Liu, and Anjie Dong*, Reactive oxygen species (ROS) responsive PEG-PCL nanoparticles with pH-controlled negative-to-positive charge reversal for intracellular delivery of doxorubicin.Journal of Materials Chemistry B2015, 3, 9397-9408.

      1.Hongzhang Deng, Jinjian Liu, Xuefei Zhao, Yuming Zhang, Jianfeng Liu, Shuxin Xu, Liandong Deng, Anjie Dong*, and Jianhua Zhang*, PEG-b-PCL copolymer micelles with the aability of pH-controlled negative-to-positive charge reversal for intracellular delivery of ddoxorubicin.Biomacromolecules2014, 15, 4281-4292.



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